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    《化學試劑》2022年第7期中英文摘要(附整期文章PDF文檔)

    發布時間: 2022-07-01 11:13:07   試劑信息網

    面向新能源的稀土催化材料研究進展

    海波1,于涵1,魏航2,褚海斌*2

    (1.內蒙古農業大學 理學院,內蒙古自治區 呼和浩特 010018;

    2.內蒙古大學 化學化工學院,內蒙古自治區 呼和浩特 010021) 

     

    摘要稀土元素基于其4f電子層的特殊排列方式,具有豐富的電子能級、多變的氧化態、獨特的氧化還原能力及儲氧能力,近年來在催化領域受到了研究者的關注,并展現出巨大的應用市場和發展潛力。綜述了近年來含稀土元素的催化材料在生物質轉化及電催化反應中的最新進展,包括甘油氧化、甲醇電氧化等反應。介紹了稀土元素提高催化反應性能的相關原因。最后討論了稀土催化材料在設計和應用等方面面臨的挑戰,并對其未來的發展進行了展望。

    關鍵詞稀土元素;催化劑;生物質轉化;電催化;研究進展

    中圖分類號:O614.33    文獻標識碼:A       文章編號:0258-32832022

     

    Research Progress of Rare Earth Catalytic Materials toward New Energy HAI Bo1, YU Han1, WEI Hang2, CHU Hai-bin*2 (1. Department of Science, Inner Mongolia Agricultural University, Hohhot 010018, China; 2. College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, China)

    AbstractBased on the special arrangement of the 4f electron layer, rare earth elements have rich electron energy levels, variable oxidation states, unique redox ability, and oxygen storage capacity. In recent years, they have attracted much attention in the field of catalytic research field and shown great application market and development potential. We provide a brief overview on rare earth elements-based catalytic materials in biomass conversion and electrocatalytic reactions, including glycerol oxidation and methanol oxidation reactions, and introduce the reasons why rare earth elements improve the catalytic performance. Finaaly, the challenges in design and application of rare earth-based catalysts are discussed, and their future development is prospected.

    Key wordsrare earth element; catalyst; biomass conversion; electrocatalysis; research progress

    引用本文:海波,于涵,魏航,等.面向新能源的稀土催化材料研究進展[J].化學試劑,2022,447941-951.

     

     

    基于近紅外和中紅外光譜的杜仲產地溯源

    劉庭愷1,胡子康1,龍婉君1,雷光華1,王芯恬1,何杰靈1 ,楊小龍1,楊健2,付海燕*1

    (1. 中南民族大學 藥學院,湖北 武漢 430074;2. 中國中醫科學院中藥研究所,北京 100700)

     

    摘要杜仲是一種重要而有價值的中藥,具有多種醫療功能,多年來在中國、日本韓國等亞洲國家被廣泛用作保健食品。杜仲的功效和質量與產地密切相關。采用近中紅外光譜與化學計量學相結合的方法,用于簡便、快速準確地鑒別杜仲產地。使k-最近鄰分析(kNN)、主成分分析-線性判別分析(PCA-LDA)和偏最小二乘判別分析(PLS-DA)模型對杜仲樣品進行了產地來源分類。結果表明,kNN模型更適合基于近紅外光譜的不同省份杜仲樣品的識別,kNN模型對來自8個省份的杜仲樣本在訓練集和測試集上的識別率達到100%,交叉驗證識別率為100%;PLS-DA模型更適合基于中紅外光譜的不同省份杜仲樣品的識別,PLS-DA模型在訓練集和測試集中對來自8個省份的杜仲樣品的識別率分別達到99.40%98.61%,交叉驗證識別率為99.11%。該方法可以快速、準確地確定杜仲的省份來源,有望應用于市場監督領域。

    關鍵詞:杜仲;地理來源;近紅外;中紅外;化學計量學

    中圖分類號:               文獻標識碼:A       文章編號:0258-32832022

     

    Origin tracing of Eucommia ulmoides by Near Mid Infrared Spectroscopy Combined with Chemometrics LIU Ting-kai1, HU Zi-kang1, LONG Wan-jun1, LEI Guang-hua1, WANG Xin-tian1, HE Jie-ling1, YANG Xiao-long1, YANG Jian2, FU Hai-yan*1 (1. School of pharmacy, Central South University for nationalities, Wuhan, Hubei 430074; 2. Institute of traditional Chinese medicine, Chinese Academy of traditional Chinese medicine, Beijing 100700), 2022, 44(7),

    Abstract: Eucommia ulmoides is an important and valuable traditional Chinese medicine with a variety of medical functions. It has been widely used as health food in Asian countries such as China, Japan and South Korea for many years. Its efficacy and quality are closely related to its origin. In this paper, a simple, rapid, and accurate identification of the origin of Eucommia ulmoides from different provinces was studied by the combination of near-infrared spectroscopy and chemometrics. The provincial origin of Eucommia ulmoides Oliv samples were classified by k-nearest neighbor analysis (kNN), principal component analysis, linear discriminant analysis (PCA-LDA) and partial least squares discriminant analysis (PLS-DA). The results show that kNN model is more suitable for the identification of Eucommia ulmoides samples from different provinces based on near-infrared spectroscopic analysis. The recognition rate of kNN model on the training set and test set of Eucommia ulmoides from 8 provinces is 100%, and the recognition rate of cross validation is 100%; PLS-DA model is more suitable for the identification of Eucommia ulmoides samples from different provinces based on mid infrared spectral analysis. The recognition rates of PLS-DA model for Eucommia ulmoides samples from 8 provinces in training set and test set are 99.40% and 98.61%, respectively, and the recognition rate of cross validation is 99.11%. Our current method can quickly and accurately determine the provincial source of Eucommia ulmoides, and is expected to be applied to the field of market supervision.

    Key words: eucommia ulmoides; geographical origin; near infrared; mid infrared; chemometrics

    引用本文:劉庭愷 ,胡子康,龍婉君,等. 基于近紅外和中紅外光譜的杜仲產地溯源[J]. 化學試劑,2022,44(7)952-959.

     

     

    天然產物及其有效成分在化妝品領域的研究與開發

    尹德航,施樂洋,葉雨涵,陳丹,王郅炫,高文超*

    太原理工大學 生物醫學工程學院,山西 太原  030024

     

    摘要:由于人們對顏值和美貌的需求,化妝品一直是人類文明中的重要研究領域和開發對象。在當代社會,隨著人們對化妝品天然、綠色、安全性的需要日益提高,對化妝品的研究開發越來越關注于天然來源的動植物提取物及其有效成分,而這些有效成分的結構特點又與化妝品本身的功能性息息相關。根據化妝品的調色增彩、防曬美白、消炎抗菌、營養保濕、防衰抗氧化、附香除臭的六大功能性,列舉了常用的幾種天然產物有效成分,并從相關成分的化學結構入手對其產生的功能特點進行了闡述,為進一步開發天然產物在日用化學品中的應用提供參考。

    關鍵詞:天然產物;化妝品;活性成分;功能性;研究

    中圖分類號: O629      文獻標識碼: A      文章編號:0258-32832022--

     

    Research and Application of Natural Products and the Related Components in Cosmetic IndustryYIN De-hang, SHI Le-yang, YE Yu-han, CHEN Dan, WANG Zhi-xuan, GAO Wen-chao*(School of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China), Huaxue Shiji,2022, 447,~

    AbstractDue to the pursuit of good-looking and beauty, cosmetics hasbeen always an important research area and object in the civilization. In modern society, with the increasing demand of the natural, green and security cosmetics, the exploration and research on cosmetics has been mainly focused on the extraction and the corresponding major components of natural products, of which the structural characters have vital relationships with their functions. This article summarized six functions of cosmetics, including color adjusting, sunscreen and whitening, anti-inflammatary and antibacterial, moisturizing, anti-aging and anti-oxidants, and odor diffusing. Furthermore, according to these functions, representative natural products and the corresponding major components were classified, and the features and relationships between structures and functions were also illustrated to provide some hits for the application and exploration of natural products in cosmetic industry.

    Key words: natural products; cosmetics; active compound; function;research

    引用本文:尹德航,施樂洋,葉雨涵,等. 天然產物及其有效成分在化妝品領域的研究與開發[J]. 化學試劑,2022, 447960-967.

     

     

    水中抗病毒藥物前處理技術及檢測方法的研究進展

    武英欣1,黃跟平*2,鄒紅艷*1 

     (1.天津師范大學 天津市水資源與水環境重點實驗室,天津  300387;

    2.天津大學 理學院 化學系,天津  300072)

     

    摘要:抗病毒藥物是一類廣泛用于預防和治療病毒感染的藥物,由于其藥物活性較強,易導致水體生物耐藥性,對水環境有著不容忽視的潛在危害,近年來逐漸引起人們的關注。通過考察世界范圍內抗病毒藥物在地表水和污水中的相關研究,歸納總結了抗病毒藥物的水樣前處理技術和儀器分析方法。結果表明,固相萃取被廣泛用于水樣中抗病毒藥物的富集,同時一些更簡單快速的萃取技術如懸浮液滴凝固微萃取和中空纖維液相微萃取也在不斷的發展中。分析檢測主要采用液相色譜-質譜聯用技術,通過反相C18C8色譜柱以及酸性流動相的條件下進行一系列分析方法的開發和建立。目前抗病毒藥物的研究相對有限,有35種抗病毒藥物建立了相應的水樣分析檢測方法,以阿昔洛韋、拉米夫定、齊多夫定、奈韋拉平、奧司他韋為主。未來需要進一步加強水樣中抗病毒藥物的檢測,提高分析方法的靈敏度,研究抗病毒藥物的環境行為以及生態毒性,優化污水處理廠處理技術從而減少抗病毒藥物的排放。

    關鍵詞:抗病毒藥物;地表水;污水;分析方法

    中圖分類號:O657.7    文獻標識碼:A       文章編號:0258-32832022

     

    Recent Progress on Pretreatment and Analytical Methods for Determining Antiviral Drugs in Water WU Ying-xin1, HUANG Gen-ping2, ZOU Hong-yan*1  (1. Key Laboratory of Water Resources and Environment, Tianjin Normal University, Tianjin 300387, China; 2. Department of Chemistry, School of Science, Tianjin University, Tianjin 300072), Huaxue Shiji, 2022,

    AbstractAntiviral drugs have been widely used in the prevention and treatment of viral infection. Because of their strong drug activity, they cause easily biological drug resistance in water and have potential harm to the water environment. They have been gradually paid much attention in recent years. This paper summarizes pretreatment technology and instrumental analysis methods on investigations of antiviral drugs in surface water and sewage all over the world. The results show that solid phase extraction has been widely used for the enrichment of antiviral drugs in water samples. At the same time, some simpler and faster extraction technologies such as suspension droplet coagulation microextraction and hollow fiber liquid phase microextraction are also developing. A series of analytical methods have been developed and established by liquid chromatography-mass spectrometry with reversed-phase C18 or C8 chromatographic columns and acidic mobile phase. At present, studies on antiviral drugs are relatively limited. Only analysis and detection methods for water samples containing 35 antiviral drugs, mainly including acyclovir, lamivudine, zidovudine, nevirapine, and oseltamivir, have been established. In the future, it is necessary to further strengthen the detection of antiviral drugs in water samples, improve the sensitivity of analytical methods, to study the environmental behavior and ecological toxicity of antiviral drugs, and to optimize the treatment technology of sewage treatment plant, reducing the discharge of antiviral drugs.

    Key wordsantiviral drug; surface water; wastewater; analytical method

    引用本文:武英欣,黃跟平,鄒紅艷. 水中抗病毒藥物前處理技術及檢測方法的研究進展[J]. 化學試劑, 2022,447968-978.

     

     

    天然甘草酸基功能材料研究進展

    唐寧,胡君*

    (北京化工大學 北京軟物質科學與工程高精尖創新中心,北京  100029

     

    摘要:為實現2030碳達峰、2060碳中和的遠景目標,開發新型生物基原料已成發展綠色可持續材料的重要原動力之一。作為傳統中藥甘草的主要活性成分,天然甘草酸由疏水的甘草次酸和親水葡萄糖醛酸經糖苷鍵連接而成,具有優異的表面活性、自組裝性、內在還原性、剛性骨架、多反應位點以及生物相容性,是生物基材料的理想構筑基元。綜述了近5年來甘草酸在添加劑、凝膠和樹脂功能材料中的研究進展,詳細介紹了甘草酸在制備食品級乳液和泡沫穩定劑、農藥助劑、3D打印材料、刺激響應性材料、催化劑載體、柔性可穿戴應變傳感器及類玻璃高分子中的作用機制和應用前景,并展望了其未來發展趨勢。

    關鍵詞:生物基材料;甘草酸;添加劑;凝膠;類玻璃高分子

    中圖分類號:TQ28             文獻標識碼:A         文獻編號:0258-32832022

     

    Research Process of Natural Glycyrrhizic Acid-based Functional Materials TANG Ning, HU Jun* (Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China), Huaxue Shiji, 2022,447

    Abstract: In order to achieve the long-term goal of "peak carbon dioxide emissions" by 2030 and "carbon neutrality" by 2060, the development of novel bio-based raw materials has become one of the important driving forces for the green and sustainable materials. As a main active component of traditional Chinese medicine liquorice, glycyrrhizic acid (GL) consists of hydrophobic glycyrrhetinic acid and hydrophilic glucuronic acid linked by a glycosidic bond is an ideal building block for the fabrication of bio-based materials due to its good surface activity, self-assembly, intrinsic reducibility, rigid skeleton, multiple reaction sites, and biocompatibility. This paper reviews the research progress of glycyrrhizic acid-based additives, gel and resin functional materials in recent five years, especially its function mechanisms and potentials in the fields of food grade emulsions and foam stabilizers, pesticide additives, 3D printing materials, stimulus-responsive materials, catalyst carriers, flexible wearable strain sensors, and vitrimers, and prospects its development trends in the future

    Key words: bio-based material; glycyrrhizic acid; additive; gel; vitrimer

    引用本文:唐寧, 胡君. 天然甘草酸基功能材料研究進展[J]. 化學試劑, 2022, 447979-989.

     

     

    稠環與非稠環芳烴對大鼠致癌性的定量構效關系研究

    李非凡1,范騰蛟1,2,孫國輝*1,趙麗嬌1,鐘儒剛1

    1.北京工業大學 環境與生命學部 環境與病毒腫瘤學北京市重點實驗室,北京 100124;

    2.北京醫藥職工大學 醫學技術系,北京 100079)

    摘要:稠環與非稠環芳烴(FNFAHs)的致癌性與人類的健康密切相關。用傳統實驗測試方法進行毒理學研究成本昂貴、耗時,且涉及倫理問題。因此,用于致癌性預測的定量構效關系(QSAR)等計算機替代方法受到了監管機構的廣泛關注。根據嚴格的OECD指南,基于2D分子描述符采用遺傳算法(GA)結合多元線性回歸(MLR)方法建立了FNFAHs對雌性大鼠、雄性大鼠和大鼠的致癌性QSAR模型,所有模型均通過國際廣泛接受的內部和外部驗證指標,并進行應用域(AD)分析。同時,機理解釋確定了結構信息(描述符)和致癌性之間的詳細關系。此外,還首次應用所建立的模型預測了沒有實驗值的真實外部集化合物的致癌效力。就監管目的而言,所構建的模型在其AD內可用于預測新的或未經測試的FNFAHs的致癌性。

    關鍵詞:稠環與非稠環芳烴;致癌性;替代方法;定量構效關系;風險評估

    中圖分類號:R99                      文獻標識碼:A                  文章編號:

     

    QSAR Modeling on Carcinogenicity of Fused and Non-fused Aromatic Hydrocarbons (FNFAHs) Toward Rats LI Fei-fan1, FAN Teng-jiao1,2, SUN Guo-hui*1, ZHAO Li-jiao1, ZHONG Ru-gang1 (1. Beijing Key Laboratory of Environmental and Viral Oncology, Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, China; 2. Department of Medical Technology, Beijing Pharmaceutical University of Staff and Workers, Beijing 100079, China), Huaxue Shiji, 2022, 44(7)

    Abstract: The carcinogenicity of fused and non-fused aromatic hydrocarbons (FNFAHs) is closely related to human health. Traditional, experimental testing methods for toxicology research are expensive, and time-consuming and involve ethical issues. Therefore, in silico alternative methods such as the quantitative structure-activity relationship (QSAR) for the carcinogenicity prediction have attracted extensive attention from regulatory agencies. In this study, we established QSAR models of carcinogenicity of FNFAHs to female rats, male rats and rats by using genetic algorithm (GA) and multiple linear regression (MLR) based on 2D molecular descriptors in accordance with strict OECD guidelines. All models were validated using internationally accepted internal and external validation indicators, and applicability domain (AD) analysis was performed to define a reliable extrapolated chemical space. Meanwhile, the mechanism interpretation determines the detailed relationship between structural information (descriptor) and carcinogenicity. In addition, we applied the established models for the first time to predict the carcinogenic potency of real external set compounds without experimental values. In conclusion, for regulatory purposes, the models constructed in this study can be used to predict the carcinogenicity of new or untested FNFAHs with their AD.

    Key words: fused and non-fused aromatic hydrocarbons (FNFAHs); carcinogenicity; alternative method; QSAR; risk assessment

    引用本文:李非凡,范騰蛟,孫國輝,等.稠環與非稠環芳烴對大鼠致癌性的定量構效關系研究[J].化學試劑,2022,44(7):990-1000.

     

     

    曲酸類酪氨酸酶抑制劑研究進展

     

    何敏a,b,凡美艷a,b,楊維a,b,馮倩倩a,b,馬雪c,李勇軍c,王廣成*a

    貴州醫科大學 a. 貴州省藥物制劑重點實驗室/省部共建藥用植物功效與利用國家重點實驗室,

    b. 藥學院,c. 民族藥與中藥開發應用教育部工程研究中心 貴州 貴陽  550004

     

    摘要:曲酸是由曲霉屬和青霉屬等多種真菌發酵而產生的一類有機酸,具有抗細菌、抗真菌、抗氧化和抗酪氨酸酶等多種生物活性。由于曲酸具有突出的抗酪氨酸酶活性,廣泛應用于食品、化妝品、醫藥等領域。國內外學者以其為先導化合物,進行了大量的結構修飾和改造研究。根據曲酸骨架結構修飾和改造的位置進行分類,介紹近年來文獻報道具有抗酪氨酸酶活性的曲酸衍生物,以期為后續研發低毒、高效的新型曲酸類酪氨酸酶抑制劑提供參考。

    關鍵詞:曲酸;結構修飾;研究進展;酪氨酸酶抑制劑;衍生物

    中國分類號: R914; 文獻標記碼: A     文章編號0258-32832022

     

    Research Progress of Kojic Acid Derivatives as Tyrosinase Inhibitors HE Mina,b, FAN Mei-yana,b, YANG Weia,b, FENG Qian-qiana,b, MA Xuec, LI Yong-junc, WANG Guang-cheng *a (a. State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Key Laboratory of Pharmaceutics; b. Teaching and Research Section of Natural Medicinal Chemistry, School of Pharmacy; c. Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Medical University, Guiyang 55004, China), Huaxue Shiji, 2022, 447,

    Abstract: Kojic acids are a kind of organic acids produced by the fermentation of Aspergillus and Penicillium, which displayed a variety of biological activities such as antibacterial, antifungal, antioxidant, and anti-tyrosinase. Kojic acids have been widely used in food, cosmetics, medicine, and other fields due to their outstanding anti-tyrosinase activity. Various structural modification and transformation studies have been conducted with kojic acids as the lead compounds in domestic and oversea. To provide a reference for the subsequent development of new kojic acid derivatives as tyrosinase inhibitors with low toxicity and high efficiency, this paper reviewed kojic acid derivatives with tyrosinase inhibition activity reported in the literature in recent years and classified these derivatives according to the modified position of the kojic acid skeleton.

    Key words: kojic acid; structural modification; research progress; tyrosinase inhibitor;derivatives

    引用本文:何敏, 凡美艷, 楊維, . 曲酸類酪氨酸酶抑制劑研究進展[J]. 化學試劑, 2022, 447):1001-1011.

     

     

    催化基于環己二烯衍生物的轉移氫化反應研究進展

    周新悅,王曉晨*

    (南開大學 化學學院,天津  300071

     

    摘要催化氫化反應是有機合成化學的一類重要反應,除直接使用氫氣作為氫化試劑外,一些轉移氫化試劑同樣具有廣泛的應用。環己二烯衍生作為轉移氫化試劑,與常見的轉移氫化試劑Hantzsch酯相似,離兩個氫原子后可形成芳烴產物使體系的能量降低,同時離去的氫可以完成與不飽和底物的加成。對環己二烯衍生物參與的轉移氫化反應進行綜述,根據所使用的催化劑類型(有機硼路易斯酸、Br?nsted酸以及金屬路易斯酸)分類,簡要介紹反應機理和底物適用性,并對反應創新性和局限性進行了總結。

    關鍵詞催化氫化;轉移氫化;酸催化;環己二烯

    中圖分類號:O624.1     文獻標識碼:A     文章編號:0258-3283(2022)--

     

    Progess of Acid-catalyzed Transfer Hydrogenation with Cyclohexadienes ZHOU Xin-Yue, WANG Xiao-Chen* (College of Chemistry, Nankai University, Tianjin 300071), Huaxue Shiji, 2022, 44(7)

    AbstractCatalytic hydrogenation is an important reaction in organic synthesis. In addition to direct hydrogenation using hydrogen gas, transfer hydrogenation also has a wide range of applications. As a class of transfer hydrogenation reagents, cyclohexadienes are similar to the commonly used Hantzsch esters. After elimination of two hydrogen atoms, aromaticity can be restored, which reduces the energy of the system, whereas the leaving hydrogen atoms can add to unsaturated bonds. In this paper, the transfer hydrogenation reactions involving cyclohexadienes are reviewed. According to the types of catalysts used (boron Lewis acids, Br?nsted acids, and metal Lewis acids), their reaction mechanisms and substrate scopes are discussed.

    Key words: catalytic hydrogenation; transfer hydrogenation; acid catalysis; cyclohexadienes

    引用本文:周新悅,王曉晨.酸催化的基于環己二烯衍生物的轉移氫化反應[J].化學試劑,2022,4471012-1019.

     

     

    生物樣品中短鏈脂肪酸的分析方法研究進展

     

    麥子盈1,2,覃思意1,3,李莎莎*1,2,4,黃文靜1,2,李冰3,4,何永寧1,賈彬1,王樂琪1,2,嚴詩楷1,2,3,4,肖雪*1

    1. 廣東藥科大學 中醫藥研究院 中藥學院 廣東省代謝病中西醫結合研究中心,廣東 廣州  510006;

    2. 廣州中醫藥大學第二附屬醫院,廣東 廣州  510120;

    3. 上海交通大學 藥學院,上海  2002404.;4. 中藥制藥共性技術國家重點實驗室,山東 臨沂  276000

     

    摘要: 短鏈脂肪酸(Short-Chain Fatty Acids, SCFAs)是膳食纖維在腸道中經微生物代謝后的主要終產物,是腸道微生物與宿主間重要的信息傳遞使者。SCFAs作為關鍵介質直接或間接在機體多個器官和組織中發揮著重要的生理作用,其準確定量對于研究生物體內SCFAs的產生、變化規律,對于揭示腸道微生物與人類健康之間復雜關系具有重要的意義。SCFAs在人體內分布廣泛,具有分子量小、易揮發、紫外吸收弱等特點,且不同生物樣品之間種類及含量相差較大,因此,SCFAs分析檢測方法一直是研究的難點。在系統介紹SCFAs的來源、種類及分布的基礎上,對其常用的分析檢測方法進行總結,以期為進一步開發高效和靈敏的SCFAs分析方法提供參考。

    關鍵詞:短鏈脂肪酸;生物樣品;前處理技術;檢測方法;

    中圖分類號:R917          文獻標識碼:A            文獻編號:0258-32832022

     

    Progress of Analytic Methods for Short-Chain Fatty Acids on Biological Samples MAI Zi-ying1,2, QIN Si-yi1,3, LI Sha-sha*1,2,4, HUANG Wen-jing1,2, LI Bing3,4, HE Yong-ning1, JIA Bin1, WANG Le-qi1,2, YAN Shi-kai1,2,3,4, XIAO Xue*1 (1. Institute of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Guangdong Metabolic Disease Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China; 2. The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120; 3. School of Pharmacy,Shanghai Jiao Tong University,Shanghai 200240,China; 4. State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Linyi 276000, China), Huaxue Shiji, 2022, 44(7),

    Abstract: Short-chain fatty acids (SCFAs) are the major end products of intestinal microbial metabolism of dietary fiber, as well as important information messengers between host and intestinal microbes. SCFAs play important physiological roles as key mediators in various organs and tissues of the body. Therefore, accurate determination of SCFAs has great significance for studying the production, transformtion of SCFAs in organisms, and revealing the intricate relationship between colonic microbes and human health. However, SCFAs have properties of low molecular weight, volatile, and weak ultraviolet absorption, and SCFAs are widely distributed in the human body, and the species and content in different biological samples differ greatly. Thus, the detection and analysis of SCFAs are always crucial and difficult issues. This paper comprehensively summarizes the analytical methods of SCFAs based on the overview of the sources and types of short-chain fatty acids, to give a reference for the further development of efficient and sensitive SCFAs analytic methods.

    Key words: short-chain fatty acids (SCFAs); biological sample; pretreatment technology; detection method

    引用本文:麥子盈, 覃思意, 李莎莎, . 生物樣品中短鏈脂肪酸的分析方法研究進展[J]. 化學試劑, 2022, 44(7)1020-1027.

     

     

    葡萄籽-菊花-三七復合物的急毒、遺傳毒性及長期毒性研究

     

    張佳a,b,楊靜*a,b

    西北大學 a.化工學院,b.西北大學生物醫藥研究院,陜西 西安  710069

     

    摘要:以葡萄籽-菊花-三七復合物為研究對象,依據食品安全性毒理學評價程序和方法(GB 15193-2014)進行急毒、遺傳毒性以及長期毒性評價,為三者復配的安全應用提供實驗參考。結果表明,小鼠急性經口毒性試驗中最大耐受劑量(MTD> 15.0 g/kg·BW,屬無毒級別。三項遺傳學毒性試驗結果顯示均為陰性,沒有發現致突變作用,說明葡萄籽-菊花-三七復合物無遺傳學毒性。大鼠28 d喂養試驗中,各劑量組(4.0、2.01.0 g/kg·BW)試驗動物生長狀況良好,動物體重、動物進食量以及食物利用率、血液學和血清生化學、大鼠臟器系數等指標與空白對照組相比均無顯著性差異,且大鼠組織經解剖檢測均未見明顯的病理組織學異常。綜上所述,葡萄籽-菊花-三七復合物無可見毒副作用,具有較高的食用安全性。

    關鍵詞:葡萄籽;菊花;三七;復配配方;毒理學;安全性; 

    中圖分類號:R9          文獻標識碼:A       文章編號:0258-32832022

     

    Study on Acute, Genetic and Long-Term Toxicities of Grape Seed-Chrysanthemum-Panax Notoginseng Complex ZHANG Jiaa,b, YANG Jing*a,b (a.School of Chemical Engineering, b. Biotech. & Biomed. Research Institute, Northwest University), Huaxue Shiji, 2022,

    Abstract: The toxicology and safety of grape seed, chrysanthemum, and notoginseng extracts were evaluated to provide the scientific basis for their safe combined applications. Acute oral, genetic, and 30-day oral toxicity tests were performed according to the national standard of “Procedure and methods of food safety toxicological assessment” (GB 15193-2014). The maximum tolerated dose (MTD) in the acute oral toxicity test was more than 15.0 g/kg·BW in mice, indicating grape seed-chrysanthemum-panax notoginseng complex was non-toxic. In the three genotoxicity tests of ames test, the micronucleus test of mice erythrocyte and mouse spermatocyte chromosomal aberration test, the results were all negative, and no mutagenic effect was found, indicating that grape seed-chrysanthemum-panax notoginseng complex has no genotoxicity. In the 28-day oral toxicity test, the rats in each group (1.0, 2.0 and 4.0 g/kg·BW) grew well, and there were no significant differences in body weight, food intake, food utilization efficiency, hematology and serum biochemistry, organ/body weight ratio comparing with the blank control group. And no obvious histopathological changes were found. All the toxicology data from this research verified that the grape seed-chrysanthemum-panax notoginseng complex was safe and non-toxic with good edible safety.

    Key words: grape seed; chrysanthemum; panax notoginseng; compound formula; toxicology; safety

    引用本文張佳, 楊靜. 葡萄籽-菊花-三七復合物的急毒、遺傳毒性及長期毒性研究[J]. 化學試劑, 2022, 4471028-1035.

     

     

    磷摻雜鎳鐵氮碳材料的制備及其鋅空氣電池應用研究

     

    馬莽1,李宗閣2,張國新*2

    (1.中國石化集團南京化學工業有限公司,江蘇 南京  210048;

    2.山東科技大學 儲能技術學院,山東 青島  266590

     

    摘要:以氯化亞鐵、2-(三苯基膦)溴化鎳TMP為金屬源,甲酰胺中的氮原子、2-(三苯基膦)溴化鎳中的磷原子為雜原子摻雜源,采用水熱及后續高溫焙燒的方法,合成了磷摻雜鎳鐵氮碳材料P-NiFe-NC,構建了相比無磷摻雜的鎳鐵氮碳(NiFe-NC)更高活性的多孔磷摻雜鎳鐵氮碳材料。所制備的P-NiFe-NC材料表現出較高的氧氣還原反應(ORR活性,在堿性介質中ORR半波電位高達0.868 V。此外,材料組裝的鋅空氣電池具有出色的比功率密度和優秀的循環穩定性。

    關鍵詞:過渡金屬;碳材料;還原反應;鋅空氣電池

    中圖分類號:O646     文獻標識碼:A      文章編號:0258-3283(2022)--

     

    Preparation of Phosphorus-Doped Nickel-Iron-Nitrogen-Carbon Material and Its Zinc-Air Battery Application MA Mang1, LI Zong-ge2, ZHANG Guo-xin2* (1. SINOPEC Nanjing Chemical Industries Co., Ltd., Nanjing 210048, China; 2. Department of Energy Storage Technology, Qingdao 266590, China), Huaxue Shiji, 2022,

    Abstract: Ferrous chloride and bis(triphenylphosphine) nickel bromide (TMP) were used as the metal sources and the nitrogen in formamide and phosphorus in bis(triphenylphosphine) nickel bromide were applied, respectively, as the heteroatom doping sources, realizing the efficient synthesis of phosphorus-doped nickel-iron-nitrogen carbon (P-NiFe-NC) material through using the combined hydrothermal and subsequent pyrolysis methods. Highly active sites were constructed on porous phosphorus-doped binary metal-nitrogen-carbon materials in comparison with the corresponding phosphorus-free material. The prepared P-NiFe-NC material exhibited very high ORR activity, realizing a very high ORR half-wave potential of 0.868 V in alkaline medium. In addition, the P-NiFe-NC material-assembled zinc-air battery possessed a large specific power density and extraordinary cycling stability.

    Key words: transition metal; carbon materials; oxygen reduction reaction; zinc-air battery

    引用本文:馬莽, 李宗閣, 張國新. 磷摻雜鎳鐵氮碳材料的制備及其鋅空氣電池應用研究[J]. 化學試劑, 2022,4471036-1043.

     

     

    農田土壤中有機磷酸酯的污染狀況及健康風險研究進展

    王濤,張虹*,王耀強,李旖曦,張勇,韓永和* 

    福建師范大學 環境科學與工程學院 福建省污染控制與資源循環利用重點實驗室,福建 福州 350007

     

    摘要:隨著溴代阻燃劑的被禁用或限制使用,有機磷酸酯Organophosphate Esters,OPEs已成為其主要替代品被廣泛應用于各類商業及工業產品。由于OPEs具有毒性且容易釋放到環境中,引起了諸多關注。目前已在多種環境基質中發現了OPEs的存在,其中土壤被認為是OPEs的主要賦存介質,而農田土壤與人類的食物鏈關系密切,其污染問題值得重視。從農田土壤的角度出發,分析了OPEs的主要來源、分布情況和植物的吸收、轉運、代謝以及對人體暴露的影響。結果顯示,農田土壤中OPEs對人體健康構成的絕對風險不高,但OPEs在土壤環境中持續積累會對人體產生潛在威脅,因此有必要進一步探討其環境行為及其健康風險。

    關鍵詞:有機磷酸酯;農田土壤;污染分布;人體暴露;健康風險

    中圖分類號:X5          文獻標識碼:A      文章編號:

     

    Pollution Situation and Health Risk Assessment of Organophosphate Esters in Farmland Soil: A review WANG Tao, ZHANG Hong*, WANG Yao-qiang, LI Yi-xi, ZHANG Yong, HAN Yong-he* (Fujian Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Fujian Normal University,  Fuzhou 350007, China)

    Abstract: With the access to brominated flame retardants being banned or restricted, organophosphate esters (OPEs) have been widely used as the main substitutes in a variety of commercial and industrial products. They have raised great concern because of their toxicity and easy release into the environment. At present, OPEs have been found in various environmental substrates, among which soil is considered to be the main sink of OPEs. Farmland soil is closely related to human food chain, and its pollution problem deserves attention. This paper analyzes the main source and distribution of OPEs, as well as the uptake, translocation and metabolism of plants and their impact on human exposure from the perspective of farmland soil. The results showed that the absolute risk of OPEs to human health in farmland soil was not high, but the continuous accumulation of OPEs in soil environment would cause potential threats to human health, so it is necessary to further explore the environmental behavior and health risks of OPEs.  

    Key words: organophosphate esters; farmland soil; pollution distribution; human exposure; health risks

    引用本文:王濤,張虹,王耀強,等.農田土壤中有機磷酸酯的污染狀況及健康風險研究進展[J].化學試劑,2022,4471044-1053.

     

     

    嗎啉類衍生物的合成與HIV-1蛋白酶抑制活性的研究

    楊帆1,周慧宇2,王玉成2,朱梅*2

    (1. 海軍軍醫大學第三附屬醫院,上海 201805;

    2. 中國醫學科學院 北京協和醫學院藥生物技術研究所,北京 100050)

     

    摘要:為探索有效的抗HIV-1活性化合物,通過開環反應、磺?;〈磻?、還原反應、氧化反應、脫Boc保護基反應、甲氨基取代反應、酰胺縮合反應等步驟設計合成7個嗎啉類目標化合物,并經1HNMR 、13CNMRHR-MS進行結構確證。利用熒光共振能量轉移方法進行體外HIV-1蛋白酶抑制活性評價,該類化合物顯示出一定的HIV-1蛋白酶抑制活性。其中化合物(R)-N-((2S, 3R)-3-羥基-4-((4-羥基-N-異丁基苯基)磺酰胺基)-1-苯基丁烷-2-)嗎啉-3-甲酰胺的IC50值為30.23 nmol/L,同時分子對接結果揭示了化合物與HIV-1蛋白酶可能的結合模式,為該類化合物的進一步優化改造提供了依據。

    關鍵詞:嗎啉類衍生物;合成;HIV-1蛋白酶;抑制活性;分子對接

    中圖分類號:R914    文獻標識碼:A       文章編號:0258-3283(2022)

     

    Synthesis and Biological Evaluation of Morpholine Derivatives with Potency against HIV-1 Protease YANG Fan1, ZHOU Hui-yu2, WANG Yu-cheng2, ZHU Mei*2 (1. The Third Affiliated Hospital of Naval Medical University, Shanghai 201805, China; 2. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China), Huaxue Shiji, 2022, 44(7),

    Abstract: For the aim of exploring compounds with activity against HIV-1, seven HIV-1 protease inhibitors containing the morpholine core were designed and synthesized via reactions of the ring opening, sulfonyl substitution, reduction, oxidation, deprotection of the Boc-protecting group, methylamino substitution, and the amide condensation. Their structures were confirmed by 1HNMR, 13CNMR, and HR-MS. In addition, the HIV-1 protease inhibitory activity assay was conducted using the fluorescence resonance energy transfer method. The results indicated that these compounds exhibited certain enzymatic inhibitory activity, compound (R)- N-((2S,3R)-3-hydroxy-4-((4-hydroxy-N-isobutylphenyl)sulfonamido)-1-phenylbutan-2-yl)morpholine-3-carboxamide with the IC50 value of 30.23 nmol/L. Meanwhile, the molecular modeling study furnished the possible binding feature of this compound and the protease, which provided basis for further optimization of this kind of compounds.

    Key words: morpholine derivatives; synthesis; HIV-1 protease; inhibition; molecular docking

    引用本文:楊帆,周慧宇,王玉成,等. 嗎啉類衍生物的合成與HIV-1蛋白酶抑制活性的研究[J]. 化學試劑,2022,4471054-1062.

     

     

    二硫化鉬的制備及其電化學傳感應用研究進展

     

    孫譽銖,張立兵*,張瑞中*

    (天津大學 理學院 化學系,天津  300072

     

    摘要:隨著社會的不斷發展和進步,食品安全、環境保護、生物反恐、臨床檢驗等領域對快速、高靈敏和高選擇性檢測樣品的傳感器件的需求不斷增加。電化學傳感器可實現快速、靈敏、簡便、低成本和在線檢測,而納米材料的電化學信號檢測放大作用為提高電化學傳感器性能提供了極大動力。二硫化鉬MoS2因其獨特的帶隙和結構以及優異的性能而被廣泛應用于多個領域,是目前研究人員討論熱度最高的納米材料之一。首先詳細總結了二硫化鉬的自上而下自下而上兩大類制備方法,接著重點總結了二硫化鉬及其復合材料在生物分子、藥物分子以及環境污染物的電化學傳感器構建方面的應用研究,最后對基于二硫化鉬及復合材料在電化學傳感方面所面臨的機遇和挑戰進行了討論。

    關鍵詞:二硫化鉬;納米材料;復合材料;電化學傳感

    中圖分類號:O646      文獻標識碼:A      文章編號:0258-32832022

     

    Progress in Preparation of Molybdenum Disulfide and its Application in Electrochemical Sensors SUN Yu-Zhu, ZHANG Li-Bing*, ZHANG Rui-Zhong* (Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, China), Huaxue Shiji, 2022, 44(7)

    AbstractWith the continuous development and progress of society, the demand for fast, highly sensitive and highly selective sensors for sample detection is increasing in food safety, environmental protection, bioterrorism, clinical laboratory and other fields. Electrochemical sensors can achieve rapid, sensitive, simple, low-cost and on-line detection, and the electrochemical signal detection amplification of nanomaterials provides a great power to improve the performance of electrochemical sensors. Molybdenum disulfide (MoS2) has been widely used in many fields due to its unique band gap, structure and excellent properties. It is one of the most popular nanomaterials discussed by researchers at present. In this review, we first summarized the "top-down" and "bottom-up" preparation methods of molybdenum disulfide in detail, and then summarized its application and composite materials in the construction of electrochemical sensors for biomolecules, drug molecules and environmental pollutants. Finally, the opportunities and challenges in electrochemical sensing based on MoS2 and composite materials are discussed.

    Key wordsmolybdenum disulfide; nanomaterial; composite material; electrochemical sensing

    引用本文:孫譽銖, 張立兵, 張瑞中.二硫化鉬的制備及其電化學傳感應用研究進展[J].化學試劑, 2022, 447):1063-1070.

     

     

    非晶合金在水處理應用中的研究進展

    梁雄,張振軒*,馬將*

    (深圳大學 機電與控制工程學院,廣東 深圳  518060

     

    摘要:非晶合金又稱金屬玻璃,是屬于能量狀態豐富的非平衡態亞穩材料。開發非晶合金新的功能性應用是當前材料科學及工程領域的研究前沿及熱點。由于非晶合金的高導電性、抗腐蝕性以及良好的生物相容性近年來已經被成功作為一種環境友好的催化劑應用于水處理領域中染料廢水的降解。一方面,非晶合金如鐵基非晶合金因本身具有較低的氧化還原電位使其可以直接作為電子供體對水中的有機污染物進行還原降解;另一方面,非晶合金結合高級氧化技術(如類芬頓反應)可以對有機污染物實現更加徹底的降解及礦化,將其變成二氧化碳和水。重點介紹了非晶合金在水處理應用中的研究背景、制備方法、催化降解性能和機制等內容,旨在為非晶合金在深度凈水處理技術的催化應用提出新的發展方向,并為未來大規模工業應用提供有價值的科學參考。

    關鍵詞:非晶合金;金屬玻璃;水處理;高級氧化技術;催化降解

    中圖分類號:O643.3      文獻標識碼:A      文章編號:0258-3283(2022)--

     

    Progress on Application of Amorphous Alloys in Water Treatment LIANG Xiong, ZHANG Zhen-xuan*, MA Jiang* (College of Mechatronics and Control Engineering, Shenzhen University, Shenzhen 518060, China)

    Abstract: Amorphous alloys, also known as metallic glasses, are non-equilibrium metastable materials with rich energy state. The development of new functional applications of amorphous alloys is the research frontier and hotspot in the field of materials science and engineering. Due to their high conductivity, corrosion resistance, and good biocompatibility, amorphous alloys have been successfully used as a class of environment-friendly catalysts in the degradation of dye wastewater in the field of water treatment in recent years. On the one hand, amorphous alloys such as iron-based amorphous alloys can be directly used as electron donors to reduce and degrade organic pollutants in water matrix owing to their low redox potential. On the other hand, amorphous alloys combined with advanced oxidation processes (such as Fenton-like reaction) can degrade and mineralize organic pollutants more thoroughly, transforming them into carbon dioxide and water. This paper focuses on the research background, preparative methods, catalytic degradation performance, and mechanism of amorphous alloys in water treatment, aiming to put forward new development directions for catalytic application of amorphous alloys in the field of advanced water purification technology, as well as to provide valuable scientific reference for large-scale industrial application in the future.

    Key words: amorphous alloys; metallic glasses; water treatment; dye wastewater; Fenton-like reaction

    引用本文:梁雄,張振軒,馬將.非晶合金在水處理應用中的研究進展[J].化學試劑,2022,4471071-1078.

     

     

    2022化學試劑第7期PDF文檔.pdf

     

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